Dual action-based approaches to antibacterial agents

Curr Med Chem. 2007;14(13):1459-77. doi: 10.2174/092986707780831168.

Abstract

This review collates and analyses recent work done on dual action approaches to tackling the mounting health problem of resistance by human pathogenic bacteria to antibacterial agents. In particular the areas reviewed include the use of two drugs in combination, dual action prodrugs, and dual action drugs (or hybrid drugs).

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacokinetics
  • Anti-Bacterial Agents / pharmacology*
  • Bacteria / drug effects
  • Models, Molecular
  • Prodrugs
  • Structure-Activity Relationship

Substances

  • Anti-Bacterial Agents
  • Prodrugs