Abstract
The interaction of pentobarbitone sodium with three analeptics viz. micoren, pentylenetetrazol and methedrine was studied in mice. Micoren prolonged pentobarbitone sleeping time. pentylenetetrazol shortened the sleeping time. Methedrine also shortened the sleeping time, but clonic convulsions of mild to severe intensity were noticed 45-60 minutes after the drug injection.
MeSH terms
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Aminobutyrates / pharmacology
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Animals
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Central Nervous System Stimulants / pharmacology*
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Drug Synergism
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Female
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Male
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Methamphetamine / pharmacology
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Mice
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Pentobarbital / antagonists & inhibitors
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Pentobarbital / pharmacology*
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Pentylenetetrazole / pharmacology
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Sleep / drug effects*
Substances
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Aminobutyrates
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Central Nervous System Stimulants
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Methamphetamine
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Pentobarbital
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Pentylenetetrazole