Contribution of a new mutation in parE to quinolone resistance in extended-spectrum-beta-lactamase-producing Escherichia coli isolates

J Clin Microbiol. 2007 Aug;45(8):2740-2. doi: 10.1128/JCM.01093-07. Epub 2007 Jun 13.

Abstract

Mutations in the quinolone resistance-determining regions of gyrA, gyrB, parC, and parE were studied in 30 fluoroquinolone-resistant clinical isolates of Escherichia coli producing extended-spectrum beta-lactamases. Ten isolates showed a mutation in parE that was significantly associated with an increase in the MIC for fluoroquinolones.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • DNA Topoisomerase IV / genetics*
  • Drug Resistance, Bacterial / genetics*
  • Escherichia coli / drug effects*
  • Escherichia coli / genetics*
  • Escherichia coli / isolation & purification
  • Escherichia coli Infections / microbiology
  • Fluoroquinolones / pharmacology*
  • Humans
  • Microbial Sensitivity Tests
  • Mutation
  • Mutation, Missense / genetics*

Substances

  • Anti-Bacterial Agents
  • Fluoroquinolones
  • DNA Topoisomerase IV