Acute monoblastic leukemia (FAB-M5b) with t(8;14)(p11;q11.1)

M L Slovak; L Nemana; S T Traweek; J A Stroh

doi:10.1016/0165-4608(91)90176-u

Acute monoblastic leukemia (FAB-M5b) with t(8;14)(p11;q11.1)

Cancer Genet Cytogenet. 1991 Oct 15;56(2):237-42. doi: 10.1016/0165-4608(91)90176-u.

Authors

M L Slovak¹, L Nemana, S T Traweek, J A Stroh

Affiliation

¹ Department of Cytogenetics, City of Hope National Medical Center, Duarte, CA.

PMID: 1756469
DOI: 10.1016/0165-4608(91)90176-u

Abstract

A case of acute monocytic leukemia (FAB-M5b) expressing natural killer cell-associated antigens containing a t(8;14)(p11;q11.1) is presented. We interpret this translocation to represent a variant of the t(8;16) previously reported in FAB-M5b. These findings support the contention that the 8p11 breakpoint site is the critical junction in the oncogenesis of acute monoblastic leukemia with differentiation.

Publication types

Case Reports
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Aged
Aged, 80 and over
Chromosomes, Human, Pair 14*
Chromosomes, Human, Pair 8*
Humans
Immunophenotyping
Karyotyping
Leukemia, Monocytic, Acute / genetics*
Male
Translocation, Genetic*

Grants and funding

CA-33572/CA/NCI NIH HHS/United States