Glutaraldehyde activation of polymer Nylon-6 for lipase immobilization: enzyme characteristics and stability

Bioresour Technol. 2008 May;99(7):2566-70. doi: 10.1016/j.biortech.2007.04.042. Epub 2007 Jun 11.

Abstract

An extracellular alkaline lipase of a thermo tolerant Bacillus coagulans BTS-3 was immobilized onto glutaraldehyde activated Nylon-6 by covalent binding. Under optimum conditions, the immobilization yielded a protein loading of 228 microg/g of Nylon-6. Immobilized enzyme showed maximum activity at a temperature of 55 degrees C and pH 7.5. The enzyme was stable between pH 7.5-9.5. It retained 88% of its original activity at 55 degrees C for 2h and also retained 85% of its original activity after eight cycles of hydrolysis of p-NPP. Kinetic parameters Km and Vmax were found to be 4mM and 10 micromol/min/ml, respectively. The influence of organic solvents on the catalytic activity of immobilized enzyme was also evaluated. The bound lipase showed enhanced activity when exposed to n-heptane. The substrate specificity of immobilized enzyme revealed more efficient hydrolysis of higher carbon length (C-16) ester than other ones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Caprolactam / analogs & derivatives*
  • Caprolactam / chemistry
  • Enzyme Stability
  • Enzymes, Immobilized / metabolism*
  • Glutaral / pharmacology*
  • Hydrolysis
  • Kinetics
  • Lipase / metabolism*
  • Polymers / chemistry*
  • Substrate Specificity

Substances

  • Enzymes, Immobilized
  • Polymers
  • nylon 6
  • Caprolactam
  • Lipase
  • Glutaral