Elastic behavior of RecA-DNA helical filaments

J Mol Biol. 2007 Jul 27;370(5):837-45. doi: 10.1016/j.jmb.2007.05.044. Epub 2007 May 18.

Abstract

Escherichia coli RecA protein forms a right-handed helical filament with DNA molecules and has an ATP-dependent activity that exchanges homologous strands between single-stranded DNA (ssDNA) and duplex DNA. We show that the RecA-ssDNA filamentous complex is an elastic helical molecule whose length is controlled by the binding and release of nucleotide cofactors. RecA-ssDNA filaments were fluorescently labelled and attached to a glass surface inside a flow chamber. When the chamber solution was replaced by a buffer solution without nucleotide cofactors, the RecA-ssDNA filament rapidly contracted approximately 0.68-fold with partial filament dissociation. The contracted filament elongated up to 1.25-fold when a buffer solution containing ATPgammaS was injected, and elongated up to 1.17-fold when a buffer solution containing ATP or dATP was injected. This contraction-elongation behavior was able to be repeated by the successive injection of dATP and non-nucleotide buffers. We propose that this elastic motion couples to the elastic motion and/or the twisting rotation of DNA strands within the filament by adjusting their helical phases.

MeSH terms

  • Adenosine Triphosphate / analogs & derivatives
  • Adenosine Triphosphate / chemistry
  • Buffers
  • DNA, Single-Stranded / chemistry*
  • DNA-Binding Proteins / chemistry*
  • Deoxyadenine Nucleotides / chemistry
  • Elasticity
  • Escherichia coli Proteins / chemistry*
  • Models, Biological*
  • Rec A Recombinases / chemistry*

Substances

  • Buffers
  • DNA, Single-Stranded
  • DNA-Binding Proteins
  • Deoxyadenine Nucleotides
  • Escherichia coli Proteins
  • adenosine 5'-O-(3-thiotriphosphate)
  • Adenosine Triphosphate
  • Rec A Recombinases
  • 2'-deoxyadenosine triphosphate