Shelf life of predosed plates containing mefloquine, artemisinin, dihydroartemisinin, and artesunate as used for in vitro Plasmodium falciparum susceptibility assessment

J Clin Microbiol. 2007 Aug;45(8):2734-6. doi: 10.1128/JCM.00479-07. Epub 2007 Jun 6.

Abstract

The shelf lives of preserved antimalarial agent-predosed plates according to the type of wrapping and the temperature of storage were studied by measuring the 50% inhibitory concentrations of drug for Plasmodium falciparum 3D7. The shelf life of mefloquine was 8 weeks at 25 degrees C; and those of artesunate, artemisinin, and dihydroartemisinin were a minimum of 24, 12, and 8 weeks, respectively, at 4 degrees C.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antimalarials / pharmacology*
  • Culture Media / chemistry*
  • Drug Stability
  • Drug Storage
  • Parasitic Sensitivity Tests / methods*

Substances

  • Antimalarials
  • Culture Media