Abstract
Clinical isolates of Klebsiella pneumoniae and Enterobacter spp. collected from 1990 through 2005 at a tertiary care center were studied for qnr genes. Isolates bearing these genes emerged in the mid-1990s, coinciding with the time of a rapid increase in fluoroquinolone resistance. Sixty percent of these isolates were ciprofloxacin susceptible by CLSI breakpoints.
MeSH terms
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Anti-Infective Agents / pharmacology*
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Bacteremia / epidemiology*
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Bacteremia / microbiology
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Bacterial Proteins / genetics*
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Ciprofloxacin / pharmacology*
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Drug Resistance, Bacterial* / genetics
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Enterobacter* / classification
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Enterobacter* / drug effects
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Enterobacter* / genetics
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Enterobacter* / isolation & purification
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Enterobacteriaceae Infections / epidemiology
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Enterobacteriaceae Infections / microbiology
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Humans
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Israel / epidemiology
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Klebsiella Infections / epidemiology
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Klebsiella Infections / microbiology
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Klebsiella pneumoniae* / drug effects
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Klebsiella pneumoniae* / genetics
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Klebsiella pneumoniae* / isolation & purification
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Microbial Sensitivity Tests / standards
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Prevalence
Substances
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Anti-Infective Agents
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Bacterial Proteins
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Qnr protein, Klebsiella pneumoniae
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Ciprofloxacin