Deprotonation and regioselective addition of 2H-pyrazolo[3,4-c]quinolines to electrophiles

J Org Chem. 2007 Jun 8;72(12):4570-3. doi: 10.1021/jo070392t. Epub 2007 May 17.

Abstract

The deprotonation and regioselective reaction of 2H-pyrazolo[3,4-c]quinolines with a variety of electrophiles is described. Electrophiles include benzaldehyde, DMF, carbon dioxide, and iodine. This method provides a direct route to a class of pharmacologically interesting compounds.

MeSH terms

  • Benzaldehydes / chemistry
  • Carbon Dioxide / chemistry
  • Dimethylformamide / chemistry
  • Iodine / chemistry
  • Pyrazoles / chemical synthesis*
  • Pyrazoles / chemistry
  • Quinolines / chemical synthesis*
  • Quinolines / chemistry

Substances

  • Benzaldehydes
  • Pyrazoles
  • Quinolines
  • Carbon Dioxide
  • Dimethylformamide
  • Iodine
  • benzaldehyde