Abstract
Mice treated with antibiotics early or late after active infection had resolved were examined for chlamydial DNA in endocervical swabs. The early eradication of infection limited oviduct pathology, despite the continued detection of chlamydial DNA by nested PCR. Late antibiotic treatment had no effect on the ability to detect DNA or oviduct pathology.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / pharmacology*
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Chlamydia Infections / drug therapy*
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Chlamydia Infections / etiology
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Chlamydia muridarum / drug effects*
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DNA, Fungal / analysis*
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DNA, Fungal / genetics
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Doxycycline / pharmacology*
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Female
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Genital Diseases, Female / drug therapy
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Genital Diseases, Female / pathology
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Mice
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Mice, Inbred BALB C
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Nucleic Acid Amplification Techniques
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Plasmids / genetics
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Polymerase Chain Reaction
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Time Factors
Substances
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Anti-Bacterial Agents
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DNA, Fungal
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Doxycycline