Abstract
The synthesis and evaluation of 2,5-bis[4-(N-ethoxycarbonyl-N'-isopropyl)amidinophenyl]furan, 2,5-bis[4-(N-2,2,2-trichloroethoxycarbonyl-N'-isopropyl)amidinophenyl]furan and 2,5-bis[4-(N-cyclopentyl-N'-2,2,2-trichloroethoxycarbonyl)amidinophenyl]furan as prodrugs of bis-N-alkylamidines are reported. The results show that the bis-2,2,2-trichloroethyl carbamates function effectively in a rat model for Pneumocystis pneumonia.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Benzamidines / chemical synthesis*
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Benzamidines / chemistry
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Benzamidines / pharmacology*
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Benzamidines / therapeutic use
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Carbamates / chemistry*
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Cysts / drug therapy
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Disease Models, Animal
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Furans / chemical synthesis
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Furans / chemistry
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Furans / pharmacology
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Furans / therapeutic use
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Lung / drug effects
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Lung / pathology
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Pneumocystis carinii / drug effects
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Pneumonia, Pneumocystis / drug therapy
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Pneumonia, Pneumocystis / microbiology
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Prodrugs / chemical synthesis*
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Prodrugs / chemistry
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Prodrugs / pharmacology*
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Prodrugs / therapeutic use
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Rats
Substances
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Benzamidines
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Carbamates
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Furans
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Prodrugs
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furamidine