Dynamic modeling for shear stress induced ATP release from vascular endothelial cells

Biomech Model Mechanobiol. 2008 Oct;7(5):345-53. doi: 10.1007/s10237-007-0088-8. Epub 2007 May 12.

Abstract

A dynamic model is proposed for shear stress induced adenosine triphosphate (ATP) release from endothelial cells (ECs). The dynamic behavior of the ATP/ADP concentration at the endothelial surface by viscous shear flow is investigated through simulation studies based on the dynamic ATP release model. The numerical results demonstrate that the ATP/ADP concentration against time at endothelium-fluid interface predicted by the dynamic ATP release model is more consistent with the experimental observations than that predicted by previous static ATP release model.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Diphosphate / metabolism
  • Adenosine Triphosphate / metabolism*
  • Animals
  • Cells, Cultured
  • Computer Simulation
  • Endothelial Cells / metabolism*
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / metabolism
  • Humans
  • Kinetics
  • Models, Cardiovascular*
  • Pulsatile Flow
  • Receptors, Purinergic P2 / metabolism
  • Stress, Mechanical*
  • Viscosity

Substances

  • Receptors, Purinergic P2
  • Adenosine Diphosphate
  • Adenosine Triphosphate