Demystifying basal-like breast carcinomas

J Clin Pathol. 2007 Dec;60(12):1328-32. doi: 10.1136/jcp.2006.041731. Epub 2007 May 11.

Abstract

"Basal" breast cancers are dominating the breast research literature at present and pathologists are under increasing pressure to evaluate for such a phenotype by their surgical and oncological colleagues. There is also much confusion about how to assess cancers, which immunohistochemical markers to use, what meaning and benefit this provides, and what the surgeons and oncologists will do with the information. Much remains to be done to answer all these questions but here we try to shed light on some of the issues and suggest what is still to come.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • Biomarkers, Tumor / metabolism
  • Breast / pathology
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / pathology*
  • Female
  • Humans
  • Middle Aged
  • Neoplasm Proteins / metabolism
  • Neoplasms, Basal Cell / drug therapy
  • Neoplasms, Basal Cell / metabolism
  • Neoplasms, Basal Cell / pathology*
  • Prognosis

Substances

  • Antineoplastic Agents
  • Biomarkers, Tumor
  • Neoplasm Proteins