Abstract
A number of RXR modulators with novel structural features were synthesized and screened in the functional assays. The synthesis and the structure-activity relationship within the series of compounds will be presented. Some in vivo data generated in the models for dyslipidemia and diabetes will also be presented.
MeSH terms
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Animals
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Diabetes Mellitus / drug therapy*
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Disease Models, Animal
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Dyslipidemias / drug therapy*
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Hypoglycemic Agents / chemical synthesis
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Hypoglycemic Agents / pharmacology*
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Hypoglycemic Agents / therapeutic use
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Quinolones / chemical synthesis
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Quinolones / pharmacology*
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Rats
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Rats, Sprague-Dawley
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Retinoid X Receptors / agonists*
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Structure-Activity Relationship
Substances
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Hypoglycemic Agents
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Quinolones
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Retinoid X Receptors