Adjunct duties for karyopherins: regulating septin sumoylation

Vikram Govind Panse; Ed Hurt

doi:10.1016/j.devcel.2007.04.007

Adjunct duties for karyopherins: regulating septin sumoylation

Dev Cell. 2007 May;12(5):669-70. doi: 10.1016/j.devcel.2007.04.007.

Authors

Vikram Govind Panse¹, Ed Hurt

Affiliation

¹ Institute of Biochemistry (IBC), Schafmattstrasse 18, ETH Zürich, CH-8093 Zürich, Switzerland.

PMID: 17488619
DOI: 10.1016/j.devcel.2007.04.007

Abstract

Karyopherins are shuttling transport receptors regulated by the small GTPase Ran, which move cargo between the nucleus and cytoplasm by passing through the nuclear pore complexes. A recent paper in Journal of Cell Biology (Makhnevych et al., 2007) highlights an additional role for karyopherins during mitosis, in regulating the sumoylation status of the septin rings.

MeSH terms

Cysteine Endopeptidases / metabolism
Cytoskeletal Proteins / metabolism*
Karyopherins / metabolism*
Nuclear Pore / metabolism
Saccharomyces cerevisiae / enzymology
Saccharomyces cerevisiae / metabolism*
Small Ubiquitin-Related Modifier Proteins / metabolism*

Substances

Cytoskeletal Proteins
Karyopherins
Small Ubiquitin-Related Modifier Proteins
Cysteine Endopeptidases
Ulp1 protease