An efficient synthesis of pyrido[2,3-d]pyrimidine derivatives and related compounds under ultrasound irradiation without catalyst

Ultrason Sonochem. 2008 Mar;15(3):217-21. doi: 10.1016/j.ultsonch.2007.03.002. Epub 2007 Mar 20.

Abstract

A series of pyrido[2,3-d]pyrimidine derivatives and related compounds were synthesized via the condensation reaction of an aldehyde, 2,6-diaminopyrimidine-4(3H)-one and either tetronic acid or 1,3-indanedione under ultrasonic irradiation without catalyst. This protocol has the advantages of higher yields, lower cost and convenient procedure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry
  • Catalysis
  • Drug Design
  • Enzyme Inhibitors
  • Ethylene Glycol / chemistry
  • Furans / chemistry
  • Indans / chemistry
  • Models, Chemical
  • Molecular Structure
  • Pyridones
  • Pyrimidines / chemical synthesis*
  • Pyrimidines / chemistry*
  • Solvents / chemistry
  • Ultrasonics*

Substances

  • 1,2-indanedione
  • Aldehydes
  • Enzyme Inhibitors
  • Furans
  • Indans
  • PD 173074
  • Pyridones
  • Pyrimidines
  • Solvents
  • Ethylene Glycol
  • tetronic acid