The anabolic and catabolic responses in bone repair

J Bone Joint Surg Br. 2007 Apr;89(4):425-33. doi: 10.1302/0301-620X.89B4.18301.

Abstract

The literature on fracture repair has been reviewed. The traditional concepts of delayed and nonunion have been examined in terms of the phased and balanced anabolic and catabolic responses in bone repair. The role of medical manipulation of these inter-related responses in the fracture healing have been considered.

Publication types

  • Review

MeSH terms

  • Anabolic Agents / therapeutic use
  • Bone Morphogenetic Proteins / therapeutic use
  • Fracture Healing / physiology*
  • Fractures, Bone / metabolism*
  • Fractures, Ununited / drug therapy
  • Fractures, Ununited / metabolism
  • Fractures, Ununited / physiopathology
  • Humans
  • Models, Biological

Substances

  • Anabolic Agents
  • Bone Morphogenetic Proteins