Simultaneous occurrence of medullary carcinoma and papillary microcarcinoma of thyroid in a patient with MEN 2A syndrome. report of a case

Tumori. 2007 Jan-Feb;93(1):109-11. doi: 10.1177/030089160709300121.

Abstract

We report a case of simultaneous multifocal medullary carcinoma and papillary microcarcinoma in a patient with several distinctive features of MEN 2A. The patient underwent total thyroidectomy and central lymph node dissection. The extreme rarity and pathological features of this occurrence are discussed. There is no known common cause of these 2 different tumor types; it may be a stochastic exception. However, several other possibilities such as a common precursor cell or a common tumorigenic stimulus offer interesting perspectives for speculation.

Publication types

  • Case Reports

MeSH terms

  • Carcinoma, Medullary / etiology
  • Carcinoma, Medullary / pathology*
  • Carcinoma, Medullary / physiopathology
  • Carcinoma, Papillary / etiology
  • Carcinoma, Papillary / pathology*
  • Carcinoma, Papillary / physiopathology
  • Female
  • Goiter / complications
  • Goiter / drug therapy
  • Humans
  • Multiple Endocrine Neoplasia Type 2a / complications*
  • Neoplasms, Multiple Primary / etiology
  • Neoplasms, Multiple Primary / pathology*
  • Neoplasms, Multiple Primary / physiopathology
  • Thyroid Neoplasms / etiology
  • Thyroid Neoplasms / pathology*
  • Thyroid Neoplasms / physiopathology
  • Thyroxine / therapeutic use

Substances

  • Thyroxine