Abstract
A 36-step synthesis was carried out in automated synthesizers to provide a synthetic key intermediate of taxol. A key step involved a microwave-assisted alkylation reaction to construct the ABC ring system from an AC precursor. Subsequent formation of the D ring afforded baccatin III, a well-known precursor of taxol.
MeSH terms
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Alkaloids / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Automation
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Centrifugation
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Chemistry, Pharmaceutical / instrumentation*
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Chemistry, Pharmaceutical / methods*
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Computers
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Filtration
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Microwaves
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Models, Chemical
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Molecular Structure
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Paclitaxel / chemical synthesis*
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Paclitaxel / chemistry
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Stereoisomerism
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Taxoids / chemistry
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Technology, Pharmaceutical / instrumentation*
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Technology, Pharmaceutical / methods*
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Temperature
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Time Factors
Substances
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Taxoids
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baccatin III
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Paclitaxel