Abstract
One of the striking regional variations in skin is its pigmentation. Yamaguchi et al. further dissect the mechanism of regional pigmentation by assessing the effects of dickkopf 1 (DKK1), an antagonist of the Wnt pathway produced in lightly pigmented skin, on melanocyte gene expression. The results provide a plethora of candidate genes that may mediate DKK1's inhibitory effects on melanocyte function.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Fibroblasts / physiology
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Gene Expression Regulation
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Glycogen Synthase Kinase 3 / genetics
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Glycogen Synthase Kinase 3 / physiology
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Glycogen Synthase Kinase 3 beta
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Humans
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Intercellular Signaling Peptides and Proteins / genetics
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Intercellular Signaling Peptides and Proteins / physiology*
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Melanocytes / physiology
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Skin Pigmentation / physiology*
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Wnt Proteins / antagonists & inhibitors
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beta Catenin / genetics
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beta Catenin / physiology
Substances
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DKK1 protein, human
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Intercellular Signaling Peptides and Proteins
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Wnt Proteins
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beta Catenin
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Glycogen Synthase Kinase 3 beta
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Glycogen Synthase Kinase 3