Serotonergic response to stress: a protective factor against abnormal dopaminergic reactivity in schizophrenia?

Eur Psychiatry. 2007 Sep;22(6):362-4. doi: 10.1016/j.eurpsy.2007.01.1219. Epub 2007 Apr 6.

Abstract

In a double-blind-crossover-study, 10 patients with schizophrenia, 10 of their unaffected siblings and 9 healthy controls randomly received metabolic stressor and placebo. A significant HVA plasma elevation in response to stress was found in siblings whose response was intermediate to that of patients and controls. Only siblings additionally displayed an exaggerated 5HIAA response.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antimetabolites*
  • Arousal / genetics
  • Cross-Over Studies
  • Deoxyglucose*
  • Dopamine / physiology*
  • Double-Blind Method
  • Female
  • Genetic Predisposition to Disease / genetics
  • Homovanillic Acid / blood*
  • Humans
  • Hydroxyindoleacetic Acid / blood*
  • Male
  • Reference Values
  • Risk Factors
  • Schizophrenia / blood*
  • Schizophrenia / genetics
  • Schizotypal Personality Disorder / blood
  • Schizotypal Personality Disorder / genetics
  • Siblings
  • Social Environment
  • Stress, Physiological / blood
  • Stress, Physiological / complications*

Substances

  • Antimetabolites
  • Hydroxyindoleacetic Acid
  • Deoxyglucose
  • Dopamine
  • Homovanillic Acid