Surgical treatment of malignancies involving the oral cavity often results in an altered anatomical situation, which may severely hamper oral function. Postoperative radiotherapy resulting in reduced salivary secretion further worsens functions such as speech, chewing (mastication) and swallowing. In order to improve oral functioning, the use of dental implants was proposed. To reconstruct the edentulous mandible, especially in cases involving postoperative irradiation, implant-borne prosthetic construction on four permucosal implants has been advocated, but this treatment concept has some practical drawbacks. As the chewing force is reduced as a result of irradiation of the masticatory muscles, it is hypothesized that a fixed prosthetic construction on only two implants is a feasible alternative. Up until now 10 patients have been treated successfully according to this concept at the authors' clinic.