Fibrous histiocytoma of the lacrimal gland

Ophthalmic Plast Reconstr Surg. 2007 Mar-Apr;23(2):145-7. doi: 10.1097/IOP.0b013e318030f5dd.

Abstract

Fibrous histiocytoma, a primary mesenchymal tumor of the orbit, is known to arise from various ocular and adnexal tissues. We are unable to find a published report of this tumor originating from the lacrimal gland. We report a case of a benign fibrous histiocytoma of the lacrimal gland in an 11 year old girl who presented with painless, progressive eyelid swelling and mild proptosis. Imaging studies revealed a discrete mass in the lacrimal gland region. The tumor was completely excised by anterolateral orbitotomy. Light microscopy showed a spindle cell tumor arising from the lacrimal gland. The tumor cells were arranged in a characteristic storiform (cartwheel) pattern with no pleomorphism or mitotic figures. Immunohistochemically, the tumor cells were focally positive for CD-68 and negative for S-100, smooth muscle actin, vimentin, and CD-34, which ruled out neurofibroma, leiomyoma, solitary fibrous tumor, and hemangiopericytoma. Based on these features, a diagnosis of benign fibrous histiocytoma was made.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers, Tumor / analysis
  • Child
  • Eye Neoplasms / chemistry
  • Eye Neoplasms / diagnostic imaging
  • Eye Neoplasms / pathology*
  • Eye Neoplasms / surgery
  • Female
  • Histiocytoma, Benign Fibrous / chemistry
  • Histiocytoma, Benign Fibrous / diagnostic imaging
  • Histiocytoma, Benign Fibrous / pathology*
  • Histiocytoma, Benign Fibrous / surgery
  • Humans
  • Lacrimal Apparatus Diseases / diagnostic imaging
  • Lacrimal Apparatus Diseases / pathology*
  • Lacrimal Apparatus Diseases / surgery
  • Neoplasm Proteins / analysis
  • Tomography, X-Ray Computed

Substances

  • Biomarkers, Tumor
  • Neoplasm Proteins