Cocaine abuse may influence the response to imatinib in CML patients

Haematologica. 2007 Mar;92(3):e41-2. doi: 10.3324/haematol.10976.
No abstract available

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / pharmacokinetics*
  • Antineoplastic Agents / therapeutic use
  • Benzamides
  • Cocaine / adverse effects
  • Cocaine / pharmacology*
  • Cocaine-Related Disorders / complications
  • Cocaine-Related Disorders / enzymology*
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme Inhibitors*
  • Cytochrome P-450 Enzyme System / physiology
  • Drug Interactions
  • Humans
  • Hydroxyurea / therapeutic use
  • Imatinib Mesylate
  • Inactivation, Metabolic
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy*
  • Leukemia, Myeloid, Chronic-Phase / complications
  • Leukemia, Myeloid, Chronic-Phase / drug therapy*
  • Liver / drug effects
  • Liver / enzymology
  • Male
  • Piperazines / adverse effects
  • Piperazines / pharmacokinetics*
  • Piperazines / therapeutic use
  • Pyrimidines / adverse effects
  • Pyrimidines / pharmacokinetics*
  • Pyrimidines / therapeutic use
  • Substrate Specificity

Substances

  • Antineoplastic Agents
  • Benzamides
  • Cytochrome P-450 Enzyme Inhibitors
  • Piperazines
  • Pyrimidines
  • Imatinib Mesylate
  • Cytochrome P-450 Enzyme System
  • Cytochrome P-450 CYP3A
  • CYP3A4 protein, human
  • Cocaine
  • Hydroxyurea