The performance of a single-walled carbon nanotube:graphite-based electrode, prepared by mixing single-walled carbon nanotubes (SWCNTs) and graphite powder, is described. The resulting electrode shows an excellent behavior for the redox of caffeic acid (CA), an important biological molecule. Due to the existing resemblance between electrochemical and biological reactions, it can be assumed that the oxidation mechanisms on the electrode and in the body share similar principles. SWCNT:graphite-based electrode presents a significant decrease in the overvoltage for the CA oxidation as well as a dramatic improvement in the reversibility of the CA redox behavior in comparison with the graphite-based and glassy carbon (GC) electrodes.