Abstract
In this issue of Chemistry & Biology, Aparicio and coworkers report that secreted bacterial cholesterol oxidase is required for the biosynthesis of the antifungal polyene pimaricin by Streptomyces natalensis [1]. Their discovery expands the inventory of tasks this biotechnologically important enzyme performs.
MeSH terms
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Antifungal Agents / chemical synthesis*
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Catalysis
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Cholesterol / chemistry
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Cholesterol / metabolism
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Cholesterol Oxidase / metabolism*
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Ergosterol / chemistry
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Ergosterol / metabolism
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Natamycin / biosynthesis*
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Pseudomonas / enzymology
Substances
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Antifungal Agents
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Natamycin
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Cholesterol
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Cholesterol Oxidase
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Ergosterol