Synthesis of multiply substituted alkylidene silacyclohexadiene derivatives via palladium-catalyzed insertion of alkynes into alkylidene silacyclobutenes

J Org Chem. 2007 Apr 13;72(8):3137-40. doi: 10.1021/jo062583m. Epub 2007 Mar 20.

Abstract

Palladium-catalyzed insertion of activated alkynes into silacyclobutene derivatives proceeded smoothly to afford exo-alkylidenesilacyclohexadiene derivatives of unique structure with diversified conjugation systems in high isolated yields. Interesting regioselectivity of insertion, which afforded only one regioisomer or a mixture of two or more regioisomers, was also observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemical synthesis*
  • Alkenes / chemistry
  • Alkynes / chemistry*
  • Catalysis
  • Cyclization
  • Cyclohexenes / chemistry*
  • Molecular Structure
  • Palladium / chemistry*
  • Stereoisomerism

Substances

  • Alkenes
  • Alkynes
  • Cyclohexenes
  • 1,4-cyclohexadiene
  • Palladium