Study of expression and functional activity of P-GP membrane glycoprotein in children with acute leukemia

Bull Exp Biol Med. 2006 Jun;141(6):727-30. doi: 10.1007/s10517-006-0264-3.
[Article in English, Russian]

Abstract

We studied expression and functional activity of tumor cell P-gp in children with various leukemia variants and analyzed its prognostic role in acute lymphoblastic leukemia. Functional activity of P-gp increased in acute myeloid leukemia, relapses of acute lymphoblastic leukemia (in comparison with primary disease), and in a group of patients in whom no remission was attained. The survival of patients with acute lymphoblastic leukemia was lower in cases with increased expression and function of P-gp.

Publication types

  • Comparative Study

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism*
  • Adolescent
  • Antibodies, Monoclonal
  • Benzimidazoles
  • Carbocyanines
  • Child
  • Child, Preschool
  • Flow Cytometry
  • Gene Expression*
  • Humans
  • Infant
  • Leukemia, Myeloid, Acute / metabolism*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism*
  • Prognosis
  • Statistics, Nonparametric
  • Survival Analysis

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Antibodies, Monoclonal
  • Benzimidazoles
  • Carbocyanines
  • 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine