ZD6474 induces growth arrest and apoptosis of human leukemia cells, which is enhanced by concomitant use of a novel MEK inhibitor, AZD6244

Leukemia. 2007 Jun;21(6):1308-10. doi: 10.1038/sj.leu.2404647. Epub 2007 Mar 15.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Combined Chemotherapy Protocols / pharmacology*
  • Apoptosis / drug effects
  • Benzimidazoles / pharmacology
  • Cell Proliferation / drug effects
  • Drug Synergism
  • Humans
  • Leukemia / drug therapy*
  • Middle Aged
  • Mitogen-Activated Protein Kinase Kinases / antagonists & inhibitors*
  • Piperidines / pharmacology
  • Quinazolines / pharmacology
  • Tumor Cells, Cultured

Substances

  • AZD 6244
  • Benzimidazoles
  • Piperidines
  • Quinazolines
  • Mitogen-Activated Protein Kinase Kinases
  • vandetanib