Intrathecal synthesis of soluble class I antigens in multiple sclerosis

J Neuroimmunol. 1992 Jan;36(1):77-9. doi: 10.1016/0165-5728(92)90032-g.

Abstract

We have studied the intrathecal synthesis of soluble class I antigens (sHLA), reflected by the index IH = (CSF sHLA/serum sHLA)/(CSF albumin/serum albumin), in multiple sclerosis (MS). IH was increased in patients in relapse, but normal in patients in remission; these findings show that there is a high lymphocyte activation within the central nervous system in patients with clinically active MS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Blood-Brain Barrier
  • Female
  • HLA Antigens / analysis
  • HLA Antigens / cerebrospinal fluid
  • Histocompatibility Antigens Class I / analysis
  • Histocompatibility Antigens Class I / cerebrospinal fluid*
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis / blood
  • Multiple Sclerosis / cerebrospinal fluid*
  • Multiple Sclerosis / physiopathology
  • Nervous System Diseases / cerebrospinal fluid
  • Solubility

Substances

  • HLA Antigens
  • Histocompatibility Antigens Class I