Improved correspondence for DTI population studies via unbiased atlas building

Med Image Comput Comput Assist Interv. 2006;9(Pt 2):260-7. doi: 10.1007/11866763_32.

Abstract

We present a method for automatically finding correspondence in Diffusion Tensor Imaging (DTI) from deformable registration to a common atlas. The registration jointly produces an average DTI atlas, which is unbiased with respect to the choice of a template image, along with diffeomorphic correspondence between each image. The registration image match metric uses a feature detector for thin fiber structures of white matter, and interpolation and averaging of diffusion tensors use the Riemannian symmetric space framework. The anatomically significant correspondence provides a basis for comparison of tensor features and fiber tract geometry in clinical studies and for building DTI population atlases.

Publication types

  • Evaluation Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Anatomy, Artistic / methods
  • Artificial Intelligence*
  • Diffusion Magnetic Resonance Imaging / methods*
  • Humans
  • Image Enhancement / methods
  • Image Interpretation, Computer-Assisted / methods*
  • Medical Illustration
  • Nerve Fibers, Myelinated / ultrastructure*
  • Neural Pathways / anatomy & histology*
  • Pattern Recognition, Automated / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity