Systematic overestimation of gene gain through false diagnosis of gene absence

Genome Biol. 2007;8(2):402. doi: 10.1186/gb-2007-8-2-402.

Abstract

The usual BLAST-based methods for assessing gene presence and absence lead to systematic overestimation of within-species gene gain by lateral transfer.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computational Biology / methods*
  • Gene Transfer, Horizontal / genetics*
  • Genome, Bacterial*
  • Genomics / methods*
  • Multigene Family / genetics*
  • Research Design*