Abstract
Three polyene antibiotics, mediomycins A (1), B (2), and clethramycin (3), were isolated from Streptomyces mediocidicus ATCC23936. Their structures were elucidated through extensive NMR study coupled with chemical reactions and MS/MS fragmentation analysis. All three compounds are linear polyenes consisting of a conjugated oxo-triene group and a hexaene moiety. Compounds 1 and 2 are new polyenes. All three compounds demonstrated a broad spectrum of antifungal activity in vitro.
MeSH terms
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Antifungal Agents* / chemistry
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Antifungal Agents* / isolation & purification
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Antifungal Agents* / pharmacology
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Fatty Acids, Unsaturated / chemistry
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Fatty Acids, Unsaturated / isolation & purification
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Fatty Acids, Unsaturated / pharmacology
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Fungi / drug effects
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Polyenes* / chemistry
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Polyenes* / isolation & purification
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Polyenes* / pharmacology
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Streptomyces / chemistry*
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Sulfuric Acid Esters / chemistry
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Sulfuric Acid Esters / isolation & purification
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Sulfuric Acid Esters / pharmacology
Substances
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Antifungal Agents
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Fatty Acids, Unsaturated
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Polyenes
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Sulfuric Acid Esters
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clethramycin
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mediomycin A
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mediomycin B