Abstract
Modulation of the proteins released during activation is one mechanism whereby aspirin may influence platelet-mediated human disease. We investigated the effect of aspirin on the platelet releasate using mass spectrometry and found that different agonists evoked different releasate profiles, with aspirin having a general moderating effect on the amount of protein released regardless of the agonist. These observations were confirmed for several cytokines using an antibody array approach.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aspirin / pharmacology*
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Blood Platelets / drug effects*
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Blood Platelets / metabolism*
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Collagen / metabolism
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Cytokines / biosynthesis
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Gene Expression Regulation*
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Humans
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Immunoenzyme Techniques
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Inflammation
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Mass Spectrometry / methods
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Platelet Aggregation
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Platelet Aggregation Inhibitors / pharmacology*
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Thrombospondins / biosynthesis
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Thromboxane B2 / biosynthesis
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Time Factors
Substances
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Cytokines
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Platelet Aggregation Inhibitors
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Thrombospondins
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Thromboxane B2
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Collagen
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Aspirin