Limited protection conferred by a DNA vaccine against a lethal pseudorabies virus infection at day 5 postvaccination

Clin Vaccine Immunol. 2007 Apr;14(4):470-3. doi: 10.1128/CVI.00428-06. Epub 2007 Feb 14.

Abstract

No pseudorabies virus (PRV)-specific neutralizing or immunoglobulin G1-type antibodies were detected in sera 5 days after injection of a DNA vaccine against PRV infection in pigs. PRV-stimulated peripheral blood mononuclear cells produced gamma interferon mRNA in vitro. Two out of five pigs recovered from lethal PRV infection without attenuation of nasal viral excretion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Herpesvirus 1, Suid / immunology*
  • Interferon-gamma / biosynthesis
  • Interferon-gamma / genetics
  • Pseudorabies / immunology
  • Pseudorabies / metabolism
  • Pseudorabies / prevention & control*
  • Pseudorabies Vaccines / immunology*
  • RNA, Messenger / metabolism
  • Swine / immunology
  • Swine / metabolism
  • Swine / virology
  • Time Factors
  • Vaccines, DNA / immunology*

Substances

  • Pseudorabies Vaccines
  • RNA, Messenger
  • Vaccines, DNA
  • Interferon-gamma