Paraneoplastic syndrome of non-small cell lung carcinoma: a case with pancytopenia, leukocytoclastic vasculitis, and hypertrophic osteoarthropathy

Lung Cancer. 2007 Jun;56(3):455-8. doi: 10.1016/j.lungcan.2007.01.008. Epub 2007 Feb 12.

Abstract

Various remote effects of cancer or paraneoplastic syndromes (PNS) are common in lung cancer, and may be the manifestation of the disease or its recurrence. The symptoms may be endocrine, neuromuscular or musculoskeletal, cardiovascular, cutaneous, hematologic, gastrointestinal, renal, or miscellaneous in nature. Since the symptoms of paraneoplastic syndromes may occur before the local symptoms of the primary tumor, it might be helpful in the early diagnosis of malignancy. We present a 65-year-old man with multiple paraneoplastic syndrome forms consisting of pancytopenia leukocytoclastic vasculitis and hypertrophic pulmonary osteoarthropathy, associated with non-small cell lung carcinoma.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biopsy, Needle
  • Carcinoma, Non-Small-Cell Lung / complications
  • Carcinoma, Non-Small-Cell Lung / diagnosis*
  • Diagnosis, Differential
  • Fatal Outcome
  • Follow-Up Studies
  • Humans
  • Lung Neoplasms / complications
  • Lung Neoplasms / diagnosis*
  • Male
  • Osteoarthropathy, Secondary Hypertrophic / diagnosis
  • Osteoarthropathy, Secondary Hypertrophic / etiology*
  • Pancytopenia / diagnosis
  • Pancytopenia / etiology*
  • Paraneoplastic Syndromes*
  • Tomography, X-Ray Computed
  • Vasculitis, Leukocytoclastic, Cutaneous / diagnosis
  • Vasculitis, Leukocytoclastic, Cutaneous / etiology*