Inflammatory tales of liver cancer

Cancer Cell. 2007 Feb;11(2):99-101. doi: 10.1016/j.ccr.2007.01.008.

Abstract

Cell culture studies have established NF-kappaB's critical role in cancer cell survival and proliferation and led to the clinical use of NF-kappaB inhibitors. However, a paper in this issue of Cancer Cell reveals an anticancer function for NF-kappaB in a mouse model where NF-kappaB activity is lost specifically in hepatocytes. These studies suggest careful examination of NF-kappaB inhibitors as a therapeutic modality for cancer.

Publication types

  • Comment

MeSH terms

  • Animals
  • Carcinoma, Hepatocellular / etiology*
  • Carcinoma, Hepatocellular / metabolism
  • Carcinoma, Hepatocellular / pathology
  • Fas-Associated Death Domain Protein / genetics
  • Fas-Associated Death Domain Protein / physiology
  • Fatty Liver / etiology*
  • Fatty Liver / metabolism
  • Fatty Liver / pathology
  • Hepatocytes / cytology*
  • Hepatocytes / metabolism
  • I-kappa B Kinase / genetics
  • I-kappa B Kinase / physiology
  • Inflammation / etiology
  • Intracellular Signaling Peptides and Proteins / genetics
  • Intracellular Signaling Peptides and Proteins / physiology*
  • Leucine Zippers
  • Liver Neoplasms / etiology*
  • Liver Neoplasms / metabolism
  • Liver Neoplasms / pathology
  • NF-kappa B / genetics
  • NF-kappa B / metabolism*

Substances

  • Fas-Associated Death Domain Protein
  • Intracellular Signaling Peptides and Proteins
  • NEMO protein, mouse
  • NF-kappa B
  • I-kappa B Kinase
  • Ikbkb protein, mouse