Abstract
A unique class of IFN-producing killer dendritic cells (IKDC) resembling natural killer cells has been defined that can recognize and lyse tumor cells through a tumor necrosis factor-related apoptosis-inducing ligand-dependent mechanism. IKDC may mediate the host-dependent antitumor activity of Gleevec/STI571 and other therapeutics that can inhibit the c-kit tyrosine kinase. IKDC represent an important new component of the innate immune system responding to cancer.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology
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Benzamides
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Dendritic Cells / drug effects
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Dendritic Cells / immunology*
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Imatinib Mesylate
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Immunotherapy / methods
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Interferon-gamma / biosynthesis
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Interferon-gamma / immunology*
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Mice
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Neoplasms, Experimental / immunology*
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Neoplasms, Experimental / therapy
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Piperazines / pharmacology
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Pyrimidines / pharmacology
Substances
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Antineoplastic Agents
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Benzamides
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Piperazines
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Pyrimidines
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Interferon-gamma
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Imatinib Mesylate