Micromanaging alternative splicing during muscle differentiation

Dev Cell. 2007 Feb;12(2):171-2. doi: 10.1016/j.devcel.2007.01.014.

Abstract

A recent report in Genes & Development by Boutz et al. (2007) demonstrates that muscle specific microRNAs (miRNAs) downregulate the alternative splicing regulator nPTB during skeletal muscle differentiation to control a potential network of splicing transitions. The results illustrate how two modes of posttranscriptional regulation combine to direct skeletal muscle development.

Publication types

  • Comment

MeSH terms

  • Alternative Splicing / genetics*
  • Animals
  • Cell Differentiation / genetics*
  • Mice
  • MicroRNAs / genetics
  • Muscle Development / genetics*
  • Muscle, Skeletal / cytology*
  • Polypyrimidine Tract-Binding Protein / genetics
  • Polypyrimidine Tract-Binding Protein / metabolism

Substances

  • MicroRNAs
  • Polypyrimidine Tract-Binding Protein