Abstract
Objective:
To investigate the relationship of BCL-10 protein and API2-MALT1 fusion gene in MALT lymphoma.
Methods:
Specimens from 86 cases of MALT lymphoma were studied by immunohistochemical staining for BCL-10. RT-PCR was used to detect the transcripts of API2-MALT1 fusion gene.
Results:
In all 10 cases of Hashimoto thyroiditis only cytoplasmic BCL-10 expression in lymphoid cells was observed. In 86 MALT lymphoma cases, 42 cases (48. 8%) exhibited BCL-10 expression in both nucleus and cytoplasm. API2-MALT1 fusion gene was detected in 35 cases (40. 7%) of MALT lymphoma. BCL-10 nuclear expression was correlated with API2-MALT1 fusion gene transcript (r = 0. 374,P = 0. 000).
Conclusion:
BCL-10 nuclear expression is correlated with API2-MALT1 fusion gene expression in MALT lymphoma.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing / genetics*
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Adaptor Proteins, Signal Transducing / metabolism
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B-Cell CLL-Lymphoma 10 Protein
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Cell Nucleus / metabolism
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Cytoplasm / metabolism
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Female
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Follow-Up Studies
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Gastric Mucosa / metabolism
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Gastric Mucosa / pathology
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Hashimoto Disease / genetics
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Hashimoto Disease / metabolism
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Hashimoto Disease / pathology
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Humans
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Immunohistochemistry
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Kaplan-Meier Estimate
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Lymphoid Tissue / metabolism
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Lymphoid Tissue / pathology
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Lymphoma, B-Cell, Marginal Zone / genetics*
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Lymphoma, B-Cell, Marginal Zone / metabolism
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Lymphoma, B-Cell, Marginal Zone / pathology
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Male
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Middle Aged
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Oncogene Proteins, Fusion / genetics*
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Oncogene Proteins, Fusion / metabolism
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Respiratory Mucosa / metabolism
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Respiratory Mucosa / pathology
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Reverse Transcriptase Polymerase Chain Reaction
Substances
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API2-MALT1 fusion protein, human
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Adaptor Proteins, Signal Transducing
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B-Cell CLL-Lymphoma 10 Protein
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BCL10 protein, human
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Oncogene Proteins, Fusion