Abstract
Two children with bone marrow necrosis at diagnosis or at relapse of acute lymphoblastic leukemia (ALL) had thrombotic complications 15 and 17 days after starting remission induction therapy including prednisone, vincristine, and L-asparaginase. The close temporal relationship of these two relatively rare events suggests that bone marrow necrosis is a predisposing factor to the development of thrombosis.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Asparaginase / administration & dosage
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Blood Proteins / analysis
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Bone Marrow / pathology*
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Child
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Child, Preschool
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Daunorubicin / administration & dosage
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Hemoglobins / analysis
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Humans
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Intracranial Embolism and Thrombosis / etiology*
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Leukocyte Count
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Male
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Necrosis / etiology*
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Platelet Count
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
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Prednisone / administration & dosage
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Remission Induction
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Vincristine / administration & dosage
Substances
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Blood Proteins
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Hemoglobins
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Vincristine
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Asparaginase
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Prednisone
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Daunorubicin