Phosphoinositides specify polarity during epithelial organ development

Frank I Comer; Carole A Parent

doi:10.1016/j.cell.2007.01.010

Phosphoinositides specify polarity during epithelial organ development

Cell. 2007 Jan 26;128(2):239-40. doi: 10.1016/j.cell.2007.01.010.

Authors

Frank I Comer¹, Carole A Parent

Affiliation

¹ Laboratory of Cellular and Molecular Biology, Center for Cancer Research, NCI, NIH, 37 Convent Drive, Bldg. 37, Room 2066, Bethesda, MD 20892, USA.

PMID: 17254962
DOI: 10.1016/j.cell.2007.01.010

Abstract

The molecular mechanisms that integrate cellular polarity with tissue architecture during epithelial morphogenesis are poorly understood. Using a three-dimensional model of epithelial morphogenesis, report that the phosphatase PTEN and phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2] regulate the GTPase Cdc42 and the kinase aPKC to generate the apical plasma membrane domain and maintain apical-basolateral polarity.

Publication types

Comment
Review

MeSH terms

Animals
Cell Membrane / metabolism
Cell Polarity / physiology*
Epithelium / embryology
Epithelium / metabolism*
Epithelium / ultrastructure
Humans
Organogenesis / physiology*
PTEN Phosphohydrolase / metabolism
Phosphatidylinositol Phosphates / metabolism
Phosphatidylinositols / metabolism*
Protein Kinase C / metabolism
Signal Transduction / physiology*
cdc42 GTP-Binding Protein / metabolism

Substances

Phosphatidylinositol Phosphates
Phosphatidylinositols
PKC-3 protein
Protein Kinase C
PTEN Phosphohydrolase
cdc42 GTP-Binding Protein