Abstract
NF-kappaB transcription factors and the signaling pathways that activate them play a critical role in cancer development, progression and therapy, and recently have become a focal point for intense drug discovery and development efforts. This article presents a critical review on the different types of inhibitors targeting the NF-kappaB pathway at several stages.
MeSH terms
-
Animals
-
Antineoplastic Agents / administration & dosage
-
Antineoplastic Agents / chemistry
-
Drug Delivery Systems / methods*
-
Humans
-
NF-kappa B / antagonists & inhibitors*
-
NF-kappa B / metabolism*
-
Neoplasms / drug therapy
-
Neoplasms / metabolism*
-
Signal Transduction / drug effects
-
Signal Transduction / physiology
Substances
-
Antineoplastic Agents
-
NF-kappa B