Abstract
A stable 1:1 host-guest complex is formed between a silicon(IV) phthalocyanine conjugated axially with two permethylated beta-cyclodextrin units and a tetrasulfonated porphyrin. The complex exhibits a light-harvesting property and works as an efficient photosensitizing system, killing HT29 human colon adenocarcinoma cells with an IC50 value of 0.09 microM. [structure: see text].
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / drug therapy*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Colonic Neoplasms / drug therapy*
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Drug Screening Assays, Antitumor
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Humans
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Indoles / chemistry*
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Indoles / radiation effects
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Isoindoles
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Light
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Molecular Structure
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Organosilicon Compounds / chemical synthesis*
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Organosilicon Compounds / pharmacology
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Organosilicon Compounds / radiation effects
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Photochemotherapy / methods
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Porphyrins / chemistry*
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Porphyrins / radiation effects
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Water / chemistry
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beta-Cyclodextrins / chemistry
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beta-Cyclodextrins / radiation effects
Substances
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Indoles
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Isoindoles
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Organosilicon Compounds
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Porphyrins
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beta-Cyclodextrins
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Water
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betadex
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phthalocyanine