Abstract
3-Alkenyl and heteroaryl chloroalcohols have been obtained in excellent enantiomeric excess (>99%) by enzymatic kinetic resolution using the haloalcohol dehalogenase HheC. Yields were close to the theoretical maximum for all substrates employed. Furthermore, the applicability of this methodology on multigram scale has been established.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alcohols / chemistry*
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Catalysis
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Chlorine / chemistry*
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Chromatography, Thin Layer
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Hydrolases / chemistry
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Hydrolysis
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Kinetics
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Models, Chemical
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Molecular Conformation
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Molecular Structure
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Stereoisomerism
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Temperature
Substances
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Alcohols
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Chlorine
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Hydrolases
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haloalcohol dehalogenase