CN-HMBC: a powerful NMR technique for the simultaneous detection of long-range 1H,13C and 1H,15N connectivities

Miriam Pérez-Trujillo; Pau Nolis; Teodor Parella

doi:10.1021/ol062511h

CN-HMBC: a powerful NMR technique for the simultaneous detection of long-range 1H,13C and 1H,15N connectivities

Org Lett. 2007 Jan 4;9(1):29-32. doi: 10.1021/ol062511h.

Authors

Miriam Pérez-Trujillo¹, Pau Nolis, Teodor Parella

Affiliation

¹ Servei de Ressonància Magnètica Nuclear, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.

PMID: 17192077
DOI: 10.1021/ol062511h

Abstract

[structure: see text] A new one-shot NMR experiment (CN-HMBC) is proposed for the simultaneous acquisition of 2D 1H,13C and 1H,15N HMBC spectra. Important sensitivity enhancements (up to 41% simultaneously for both 13C and 15N) or time savings (about 50%) can be achieved when compared to the separate acquisition of individual HMBC spectra. The experiment is highly recommended for the complete structural analysis and simultaneous chemical shift assignments of protonated and nonprotonated 13C and 15N resonances in nitrogen-containing organic compounds.