Abstract
Five new ent-kaurane diterpenoids, epi-maoecrystal N (1), eriocalyxin G (2), maoecrystal W (3), maoecrystal X (4), and maoecrystal Y (5), along with 22 known ones, were isolated from Isodon eriocalyx (Dunn.) Hara., and their structures were determined by spectroscopic methods. All diterpenoids, except for 3 and 13, were evaluated for inhibition of the K562, T-24, Me180, QGY-7701, and BIU87 cell lines (Table 2).
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Cytotoxins / chemistry
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Cytotoxins / isolation & purification*
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Cytotoxins / pharmacology
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Diterpenes / chemistry
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Diterpenes / isolation & purification
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Diterpenes / pharmacology
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Diterpenes, Kaurane / chemistry
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Diterpenes, Kaurane / isolation & purification*
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Diterpenes, Kaurane / pharmacology
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Humans
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Isodon*
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K562 Cells
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Plant Leaves
Substances
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Antineoplastic Agents, Phytogenic
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Cytotoxins
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Diterpenes
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Diterpenes, Kaurane
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Plant Extracts