Growing human B lymphocytes in the CD40 system

Nature. 1991 Oct 17;353(6345):678-9. doi: 10.1038/353678a0.

Abstract

One approach to generating human monoclonal antibodies relies on the development of culture techniques allowing the long-term growth of most B lymphocytes, a property of the CD40 system.

MeSH terms

  • Antibodies, Monoclonal*
  • Antigens, CD / immunology*
  • Antigens, Differentiation, B-Lymphocyte / immunology*
  • B-Lymphocytes / cytology*
  • B-Lymphocytes / immunology
  • CD40 Antigens
  • Cell Division
  • Cell Line, Transformed
  • Herpesvirus 4, Human
  • Humans

Substances

  • Antibodies, Monoclonal
  • Antigens, CD
  • Antigens, Differentiation, B-Lymphocyte
  • CD40 Antigens