Use of repeating dispensers to increase the efficiency of the intramuscular myogenic cell injection procedure

Cell Transplant. 2006;15(7):659-63. doi: 10.3727/000000006783981648.

Abstract

Intramuscular myoblast transplantation in humans and nonhuman primates requires precise repetitive cell injections very close to each other. Performed with syringes operated manually throughout large regions, this procedure takes a lot of time, becoming tiring and thus imprecise. We tested two repetitive dispensers with Hamilton syringes as cell injection devices to facilitate this procedure. Monkeys received intramuscular allotransplantations of beta-galactosidase-labeled myoblasts, using either a monosyringe or a multisyringe repeating dispenser. The monosyringe repeating dispenser allowed performing cell injections faster and easier than with a manually operated syringe. The multisyringe dispenser accelerated the procedure still more, but it was not ergonomic. Biopsies of the myoblast-injected sites 1 month later showed abundant beta-galactosidase-positive myofibers, with the same density and morphological pattern observed following myoblast transplantation with a syringe operated manually. We recommend the monosyringe repeating dispenser for myoblast transplantation in skeletal muscles and maybe in the heart.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Automation
  • Cell Transplantation / instrumentation*
  • Cell Transplantation / methods
  • Injections, Intramuscular / instrumentation*
  • Injections, Intramuscular / methods
  • Macaca fascicularis
  • Muscle Development / physiology
  • Muscle, Skeletal / cytology*
  • Muscle, Skeletal / physiology
  • Myoblasts, Skeletal / cytology
  • Myoblasts, Skeletal / transplantation*
  • Myocardial Infarction / pathology
  • Myocardial Infarction / surgery
  • Syringes
  • Transplantation, Homologous / instrumentation
  • Transplantation, Homologous / methods