Association between a polymorphism in the promoter region of the TPH2 gene and the personality trait of harm avoidance

Int J Neuropsychopharmacol. 2007 Jun;10(3):401-4. doi: 10.1017/S1461145706007073. Epub 2006 Dec 19.

Abstract

In a genetic association study the role of the -703 G/T (rs4570625) polymorphism, located in the promoter region of the tryptophan hydroxylase 2 gene (TPH2), in personality traits was investigated in a sample of 404 healthy Caucasian subjects. A significant association between harm avoidance (HA), a trait related to anxiety, and the -703 G/T polymorphism was detected supporting the findings by Gutknecht and colleagues.

MeSH terms

  • Adult
  • Aging / psychology
  • Alleles
  • Anxiety / psychology
  • DNA / genetics
  • Emotions / physiology
  • Exploratory Behavior / physiology
  • Female
  • Humans
  • Male
  • Personality / genetics*
  • Personality / physiology*
  • Personality Tests
  • Polymorphism, Genetic / genetics
  • Promoter Regions, Genetic / genetics
  • Reverse Transcriptase Polymerase Chain Reaction
  • Reward
  • Sex Characteristics
  • Temperament
  • Tryptophan Hydroxylase / genetics*

Substances

  • DNA
  • TPH2 protein, human
  • Tryptophan Hydroxylase